Valerio Therapeutics

Valerio Therapeutics is a clinical-stage biotechnology company leading the way in the development of innovative DNA decoy therapeutics. Focusing exclusively on intracellular DNA-binding targets, the company designs and develops first-in-class treatments for oncology and inflammatory diseases. Valerio Therapeutics was formerly Onxeo (acquired DNA Therapeutics, a company co-founded by Marie Dutreix, Head of DNA Repair, Radiations and Innovative Cancer Therapies Team at Institut Curie in 2016).

Year of creation: 2006

Line of business: Biotechnology

Institut Curie: Behind the technology, institutional co-founder and R&D partner

TECHNOLOGY

Onxeo's technology relies on its proprietary chemistry platform platON™ that broaden the company’s product pipeline. The platform is based on a library of decoy oligonucleotides which generates disruptive compounds acting on intracellular DNA-binding targets. platON™ has already generated two very innovative molecules :

AsiDNA™

AsiDNA™ is a first-in-class DDR inhibitor, currently in clinical trials, with potential in multiple therapeutic applications, alone and in combination with DNA-damaging treatments as well as targeted therapies. Unlike inhibitors of a single DDR pathway or protein such as PARP inhibitors, AsiDNA™ acts as an agonist, upstream of multiple pathways, to divert DNA repair proteins from their true targets without inducing resistance.

OX401

OX401 is the newest addition in the pipeline, currently undergoing preclinical proof of concept studies, alone and in combination with checkpoint inhibitors. At the crossroads of DNA damage response and immunotherapy, OX401 is designed to be a next-generation PARP inhibitor that does not induce resistance but triggers a strong immune response through the activation of the STING pathway.

APPLICATIONS

The company focus on bringing first-in-class and disruptive compounds from preclinical research to proof-of-concept in man in cancer indications with high unmet needs.

AMBITION

Onxeo seek to transform breakthrough scientific opportunities into treatments through translational and clinical expertise, developing products up to the stage where they become compelling opportunities for partners.

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