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Radiation Biology

Institut Curie
07/04/2017
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Radiation therapy was born at Institut Curie after Pierre and Marie Curie discovered radium in 1898. Ever since, the institute’s physicians and scientists have been making a decisive contribution toward improving practices and technologies that aim for maximum preservation of the organs and body. Today, Institut Curie's radiation therapy equipment is a gold standard in Europe and developing of cutting-edge new technologies.
Centre de Protonthérapie de l'Institut Curie à Orsay
Pour sculpter le faisceau à la forme et à la profondeur de la tumeur tout en protégeant au maximum les tissus sains avoisinants, plusieurs dispositifs sont placés le long de celui-ci. Ils sont indispensables pour délivrer une dose d’irradiation de façon homogène à une profondeur extrêmement précise dépendante de l’énergie des protons. Ici, un « compensateur » pour ajuster la distribution de dose en profondeur. Et derrière celui-ci, le « collimateur » pour moduler dans le plan latéral la forme du dépôt d’énergie.

Ever since, the institute’s physicians and scientists have been making a decisive contribution toward improving practices and technologies that aim for maximum preservation of the organs and body. Our state of the art radiation therapy equipment is the current gold standard in Europe and the development of cutting-edge new techniques is continuous. Among the radiotherapy techniques performed at Institut Curie are external radiotherapy, modulated intensity conformal radiotherapy, proton beam radiotherapy, brachytherapy and tomotherapy.

Institut Curie's main interests focus on deciphering cellular responses to various types of radiation and covering emerging biological effects of radiation. In the field of biomedical research, we are particularly involved in optimizing the response to radiotherapy while reducing side effects.

As part of the IDEX project carried out by the Paris-Saclay University, Institut Curie will participate in the NanoTheRad project. This project seeks to develop new targeted radiotherapy strategies and also to combine them with radiosensitizing nanoagents or amplifiers for personalized medicine.

Institut Curie will deepen the therapeutic innovation axis with the study of protons and ultra-high dose rates thanks to its protontherapy center. Our teams have developed irradiation protocols with irradiation doses delivered in extremely short time frames. FLASH irradiations conserve the efficacy of the rays on the tumor cells while minimizing unwanted side effects on healthy cells. Our researchers are also developing molecules to increase tumor radiosensitivity and identify biomarkers capable of predicting tumor response to irradiation. The first clinical trials are due to be launched quickly.