Technology Transfer Office
Actualité - Partnership

Microbrain Biotech signs an exclusive license to develop neuronal screening with Institut Curie, CNRS and UPMC

Institut Curie
Institut Curie, CNRS and UPMC and the start-up MICROBRAIN BIOTECH sign an exclusive licensing agreement on a microfluidic device called a "neural diode" which makes it possible to reconstruct functional neural networks by mastering the direction and architecture. This license concerns a microfluidic chip technology transferred to MICROBRAIN BIOTECH to target the neuropharmacological and toxicological R & D market and to allow, in particular, the development of treatments against neurodegenerative diseases.
Microbrain bio

MICROBRAIN BIOTECH, a biotechnology company specializing in the design and development of microfluidic devices for the screening of neuropharmacological agents from reconstructed neural networks, signed an exclusive licensing agreement with Institut Curie, CNRS, and the University Pierre-and-Marie Curie. This agreement was set up within the framework of Curie-Cancer, the structure labeled "Institut Carnot" which conducts the research activities of the Institut Curie. It concerns an international patent protecting a microfluidic technology which makes it possible to reconstitute functional, compartmentalized and directional neural networks.

This new technology, or neuronal diode, was developed by Drs Bernard BRUGG and Jean-Michel PEYRIN at the Paris-Seine Institute of Biology (CNRS UPMC UMR8256) in collaboration with Jean-Louis VIOVY (Institut Curie & Institut Pierre -Gilles de Gennes-IPGG). It has been shown to be particularly effective in developing preclinical models of Alzheimer's disease, Parkinson's disease, or in vitro reproduction of situations of traumatic or ischemic injury. This work has been the subject of several publications in international scientific journals of reference.

The devices developed by MICROBRAIN BIOTECH target the market of neuropharmacological and toxicological R & D. To develop this technology, MICROBRAIN BIOTECH intends to adopt a double strategy. On the one hand, MICROBRAIN BIOTECH will develop proprietary products selected for their local neuroprotective activity (protection of synapses, axons) or on the functionality of reconstructed neural circuits. On the other hand, MICROBRAIN BIOTECH will offer pharmaceutical companies devices and approaches on neural networks to select and optimize the efficiency of their proprietary molecules.

A lot of research is being done to discover new treatments for neurodegenerative diseases, and to select drug candidates with no side effects. The originality of MICROBRAIN BIOTECH is to use innovative microfluidic devices composed of polydimethylsiloxane in which the neurons are arranged in a controlled architecture in order to mimic neuroanatomic pathways of interest.

« Neuronal diodes provide increased quality and reproducibility to primary and human neuronal cultures, enable the consumption of consumables (fluids, molecules, probes) and energy, and are compatible with all analytical and diagnostic tools. quantification of cell biology such as imaging, molecular biology, electrophysiology, neuro-electronic interfaces (MEA), and with multi-well analysis robots»

« This agreement illustrates the richness of the work carried out at the Institut Curie, the IBPS and the IPGG and their broad applications in terms of markets and pathologies targeted. It is a satisfaction for the Carnot Institute "Curie-Cancer" to have contributed to the signature of this agreement with a dynamic start-up that is invested in the search for new treatments against degenerative diseases which are, with the cancer and cardiovascular diseases, major public health issues with key markets.»
Amaury MARTIN, Technology Transfer Office and Carnot Curie Cancer Director

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